The German ended the 186-week reign of Serena Williams at the top of the WTA rankings following victory in the US Open earlier this month.
Kerber was runner-up to Victoria Azarenka in the last Brisbane event on the way to her maiden Grand Slam win at the Australian Open in January.
"For me, Brisbane kick-started the best season of my career this year," Kerber said.
"You have to play tournaments that will prepare you for the big moments, which for me, was winning the Australian Open and going on to be the No 1 player in the world."
Kerber will be joined in the Brisbane women's draw by world No 3 and reigning French Open champion Garbine Muguruza.
Muguruza is the second high-ranking Spaniard confirmed for the Brisbane International with Rafael Nadal headlining the men's draw.
The Brisbane International takes place from January 1-8.